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  <rdfs:Class rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC06203">
    <ns1:colonyMaintenance xml:lang="en">Homozygote x Homozygote [or Crossing to C57BL/6JJcl]</ns1:colonyMaintenance>
    <ns1:colonyMaintenance xml:lang="ja">Homozygote x Homozygote [or Crossing to C57BL/6JJcl]</ns1:colonyMaintenance>
    <ns10:citesAsAuthority rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/21089073"/>
    <ns1:references rdf:parseType="Resource">
    </ns1:references>
    <skos:altLabel xml:lang="ja">Pitx2 A-17 flox, B6-Pitx2 floxed</skos:altLabel>
    <skos:altLabel xml:lang="en">Pitx2 A-17 flox, B6-Pitx2 floxed</skos:altLabel>
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    <ns6:brs_preservationStatus rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainStatus_2"/>
    <ns7:SIO_001279 rdf:parseType="Resource">
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    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
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    <dc:description xml:lang="en">Pitx2 gene floxed mice.  A loxP site was inserted in the intron 5, and a neo cassette with a 3’ loxP site was inserted downstream of intron 5.  Homozygous mice are viable and fertile.</dc:description>
    <ns1:strainDevelopment xml:lang="en">Developed by Hidetaka Shiratori and Hiroshi Hamada, Graduate School of Frontier Biosciences, Osaka University in 2001.  G4 ES cells were used.  The transgene was injected into the pronuclei of B6C3F1 fertilized eggs.  C57BL/6 and 129 mixed background.</ns1:strainDevelopment>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <dcterms:identifier>RBRC06203</dcterms:identifier>
    <ns4:termsAndConditions xml:lang="en">In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Dyn., 240, 195-203 (2011).</ns4:termsAndConditions>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <ns1:strainDevelopment xml:lang="ja">大阪大学大学院生命機能研究科・白鳥秀卓先生、濱田博司先生ら（2001）。のG4 ES細胞（B6/129由来）を使用。129とC57BL/6の混合背景。</ns1:strainDevelopment>
    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns4:addinfo>
    <ns4:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;研究成果の公表にあたって譲渡者の指定する文献を引用する。Dev. Dyn., 240, 195-203 (2011).</ns4:termsAndConditions>
    <ns6:brs_depositedBy rdf:parseType="Resource">
    </ns6:brs_depositedBy>
    <ns1:expectedDelivery xml:lang="en">D (more than 6 months)</ns1:expectedDelivery>
    <ns1:ESCellLine>G4 [(129S6/SvEvTac x C57BL/6NCr)F1]</ns1:ESCellLine>
    <ns6:brs_hasAllele rdf:resource="http://metadb.riken.jp/db/mgi_rdf/MGI:4880738"/>
    <ns6:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns6:brs_hasGenomicFeature>
    <rdfs:label>B6.Cg-Pitx2&lt;tm1Hmd&gt;</rdfs:label>
    <rdfs:label xml:lang="en">B6.Cg-Pitx2&lt;tm1Hmd&gt;</rdfs:label>
    <ns4:application>Cre/loxP system</ns4:application>
    <ns4:resourceTypeLink rdf:resource="http://metadb.riken.jp/terms/xsearch#resource_type_targeting"/>
    <ns6:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_3"/>
    <ns1:donorDNA>phage P1 loxP sites, mouse PGK1 promoter, E.coli neo gene, mouse PGK1 polyA signal sequence, mouse Pitx2 genomic DNA</ns1:donorDNA>
    <ns6:brs_depositor xml:lang="en">Hiroshi HAMADA</ns6:brs_depositor>
    <ns5:organism rdf:parseType="Resource">
    </ns5:organism>
    <rdfs:seeAlso rdf:resource="http://www2.brc.riken.jp/lab/animal/detail.php?brc_no=RBRC06203"/>
    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/straintype_14"/>
    <ns6:brs_depositor xml:lang="ja">濱田　博司</ns6:brs_depositor>
    <ns1:expectedDelivery xml:lang="ja">D（6か月以上）</ns1:expectedDelivery>
    <dc:description xml:lang="ja">Pitx2遺伝子の第5イントロンにloxP、下流にLOXp-Pitx2遺伝子の第５イントロンにLoxP、下流にPGK-neo-loxPを挿入したマウス。ホモマウスは通常の維持繁殖には特に問題ない。</dc:description>
    <ns6:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainType_17"/>
    <ns1:isRecombinant rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean"
    >true</ns1:isRecombinant>
  </rdfs:Class>
  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1015996">
    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC06203"/>
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